Sildenafil is a cost-effective erectile dysfunction medication that contains the same active ingredient as Viagra. The results indicate that the use of sildenafil in babies who have developed such sequelae despite therapeutic hypothermia is feasible and safe. Blood pressure slightly decreased in two of the eight babies after the first dose of sildenafil, but this did not recur thereafter. The first phase of this study was not designed to establish the efficacy of sildenafil in such cases.

This is the first proof-of-concept study to attempt to repair the brain damage caused by neonatal encephalopathy. The first phase of a new clinical study conducted at the Montreal Children's Hospital (MCH) shows that the administration of sildenafil, marketed under the brand name Viagra, could be a possible solution. Established in 1904, the Montreal Children's Hospital (MCH) is Quebec’s oldest children’s hospital and the pediatric hospital of the McGill University Health Centre (MUHC).

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